| abstract |
THE INVENTION COVERS: ON A NEW COMPOUND (I) WITH ANTIVIRAL ACTIVITY AND IN PARTICULAR INHIBITOR TO THE INTEGRASE OF HIV, AND ON A MEDICAMENT CONTAINING IT, IN PARTICULAR AN HIV DRUG; AND ON A METHOD AND ITS INTERMEDIATE. IN THE NEW COMPOUND (I): Z1 IS NR4; R1 IS HYDROGEN OR LOWER ALKYL; X IS A SINGLE BINDING, A HETERROATOMA SELECTED AMONG O, S, SO, SO2, AND NH, OR LOWER ALKYLENE OR LOWER ALKENYLENE, IN WHICH HETEROATOMA MAY INTERVENE; R2 IS ARYLY OPTIONALLY SUBSTITUTED; R3 IS HYDROGEN, HALOGEN, HYDROXY, LOWER ALKYL OPTIONALLY SUBSTITUTED, ETC; AND R4 AND Z2 TAKEN TOGETHER FORM A CYCLE FOR FORMING A POLYCYCLIC COMPOUND, FOR EXAMPLE TRICYCLIC OR TETRACYCLIC. |