| abstract |
An improved chemical stability medicinal aerosol formulation product comprising a pressurized metered dose inhaler comprising an aerosol can equipped with a metering valve having seals and / or static seals in a vulcanization product of a butyl rubber elastomer composition, a crosslinking agent for butyl rubber and an accelerator for the crosslinking agent, the accelerator comprising a polysulfide compound derived from a substituted dithiocarbonic acid or a derivative thereof, the pressurized aerosol dispenser containing, in the aerosol can, a medicinal aerosol formulation comprising a long acting (beta) 2 agonist, a hydrofluorocarbon propellant, a solvent and a mineral acid as a stabilizer for the active ingredient. |