| abstract |
Invention describes new non-stoichiometric hydrated crystalline form of 6-hydroxy-3-(4-[2-piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b] thiophene hydrochloride (arzoxifene) used as up-regulator of choline acethyltransferase (ChAT). This compound can be used for treatment of disorders related to loss of oestrogen. Such as cardiovascular diseases, hyperlipidemia, osteoporosis, oestrogen dependent cancers including breast and uterine cancer, endometriosis, CNS disorders including Alzheimer's disease, prostatic cancer and benign prostatic hyperplasia. |