| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef884ad86d5537af50cfd5effdc380ba |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-09 |
| filingDate |
1998-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36af772771eddf37751d8180e90d4ccd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2ad07189aebb9dc6447dd90f6265827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5996705fc18a8fb7226a0f026dc689bf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05b51ea8cced4078dce4e4e3d09981c0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90d5ccad58846f9d3aebaf8d4e36836c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed388287b1a6e0a6c16e4bb6bb54207c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_380c0d96122fb5e5fbfb4a023c079c87
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff2dc3dd0fb9c7d8bca7282c5f16d3a5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9f93da1bca8a0cd4523b761c5726569 |
| publicationDate |
1999-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
LV-12373-A |
| titleOfInvention |
Cytotoxic 2-oxo-1-azetidinyl acetic acid ester derivatives |
| abstract |
The present invention pertains to the pharmacologically active substances, particularly to cytotoxically agents for chemotherapy for cancer. The said compounds contain modifying azetidin-2-one having specifically selected substituents in the positions 1, 3 and 4. According results of experiments the invented substances have cytotoxically quality in vitro on cell-lines HT 1080, MG-22A and B 16: by using 0.25-10 mg/ml concentrations of said substance is observable death of 50 % cells. Direct correlation between cytotoxically activity of studied compounds and their ability to induce biosynthesis of NO in cells is observed. Compounds having expressed cytotoxically activities compare with compounds having low activity have considerably extent the mentioned ability to induce biosynthesis. |
| priorityDate |
1998-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |