| abstract |
The object of the patent are the O-Acil-4-phenylcyclohexanols of the common formula (I):<IMAGE>wheren is 0 or 1;m is 1 or 2;p is 0 or 1;R<1> and R<2>, which can be similar or different, is a hydrogen atom, linear or branched lower alkyl-, alkenyl-, or alkinyl group; also, the above mentioned alkyl groups, alkynyl groups, and alkinyl groups can be substituted, or together with the nitrogen atom, to which they are attached, form the 5-7 component monocyclic heterocyclic, and the heterocyclic metylene group can be replaced by the oxygen or sulphur atom or by an imino group;R<3>, R<4>, R<5>, and R<6> is a hydrogen atom or a lower alkyl group; moreover, R<6> can be a lower alkoxy group;R<7> is a hydrogen atom, cycloalkyl group, phenyl group, which is not necessarily substituted, naftyl group, tetrohydronaftyl group, tienyl group, furanyl group or piridinyl group;A is a bond or a forked C2-17 alkylen group or C2-17 alkenylen group, C2-17 alkinylen group. The object of this patent is the method of producing this compound, the medical preparations containing the substances mentioned, and the usage of those. The offered compounds influence the biosynthesis of cholesterol. The abovementioned compounds possess antihypercholesterolemic features and are used in prophylaxis and treatment for atherosclerosis, and they inhibit 2,3-epoxycvalenalanosterolaepoxy cyclasis.<IMAGE> |