http://rdf.ncbi.nlm.nih.gov/pubchem/patent/LU-502212-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85eeafc0a14ded42c553e8b341ff82f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2287f3634494078b552cbd4e03fadd88 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-71 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate | 2022-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db27a0e524212bd29c776fc1a2094788 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b06bd46075c36fafb8eed7024c98acd4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_30a698b1eea7ecb03853e3a719f0bcd5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d71207ace3bb077ef695ffa005f5ede6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77ab764b45a2dda16dc0de70ddd9a8b0 |
| publicationDate | 2022-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | LU-502212-B1 |
| titleOfInvention | Promoter molecule capable of specifically recognizing proliferative endothelial cells and engineered cells derived therefrom |
| abstract | Provided herein is a promoter molecule capable of specifically recognizing proliferative endothelial cells, and engineered cells derived therefrom. The promoter molecule is a fusion protein, and is resulted from the fusion of deoxyribose nucleic acid sequences corresponding to humanized Apelin protein, an intramembrane hydrolyzable polypeptide and an effector, wherein the intramembrane hydrolyzable polypeptide is the minimal transmembrane core domain of natural Notch, and is partially or completely covered by the adjacent Apelin and effector in a resting state. The promoter molecule has the characteristics of highly modularized functions and recognizes proliferative endothelial cells. The humanized Apelin therein binds to an Apj receptor, a molecular marker on the surface of new blood vessels, and then the cleavage sites are identified and hydrolyzed, and the new blood vessels are specifically identified, thereby regulating the expression of predetermined genes. The promoter molecule can be used for tracing proliferative endothelial cells, indicating vascular remodeling in adults, and can also be used as therapeutics for repairing the blood-brain barrier. |
| priorityDate | 2022-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 626.