| abstract |
The present disclosure relates to the technical field of bone repair and provides a berberine/mineralized collagen-based composite membrane as well as a preparation method and an application thereof. The composite membrane of the present disclosure includes a berberine nanofiber membrane and a mineralized collagen membrane disposed on a unilateral surface of the berberine nanofiber membrane. In the present disclosure, the mineralized collagen with biomimetic mineralization capacity is combined with a Chinese materia medica monomer, berberine, the resulting bilayer composite membrane has a better effect on promoting osteogenesis; in addition, a novel dosage form of berberine is constructed, solving the disadvantages of traditional berberine dosage forms such as low bioavailability, frequent administration, serious adverse effects and so on. The present disclosure employs an electrospinning method to prepare a berberine nanofiber membrane, the berberine nanofibers are received by the mineralized collagen membrane, or after the berberine nanofiber membrane is obtained, a mineralized collagen membrane is prepared by applying on the surface of the berberine nanofiber membrane; the preparation method is simple, low in cost, and easy for industrial production. |