http://rdf.ncbi.nlm.nih.gov/pubchem/patent/LU-500595-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c065a4f9d27000de05bad4a0e4bbe795 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-531 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-20 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 |
| filingDate | 2020-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6dd047829a69b9cfa7a98facf0232776 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e961b804becd91aabb8ffa68f53e94e9 |
| publicationDate | 2022-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | LU-500595-B1 |
| titleOfInvention | miR-16 and miR-30c joint Expression Vector, Construction Method and their Use |
| abstract | The present invention belongs to the field of biomedicine, and specifically relates to the use of two small RNAs, i.e., miR-16 and miR-30c in combination for regulating the proliferation of neural stem cells. The present application conducted the following works: (1) the number of adult neural stem cells in the hippocampi of Alzheimer's disease mice increased by 1.96 times, n=6, p <0.001, under the combined action of miR?16 and miR- 30c; (2) after the miR- 16 and miR- 30c overexpression, adult neurogenesis in the subventricular zone of the lateral ventricle and adult neurogenesis in the hippocampal dentate gyrus of Alzheimer's disease mice increased by 13.90 times, n=6, p<0.001, and 6.71 times, n=6, p<0.001, respectively. miR-16 and miR-30c show a significant effect on regulating the proliferation of neural stem cells in adult Alzheimer's disease mice, which is conducive to designing targeted drugs for the treatment of Alzheimer's disease, which can be in turn used in clinic treatment of Alzheimer's disease. |
| priorityDate | 2020-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 117.