abstract |
The present invention provides mutants of the Rb gene and p53 gene and methods of using these mutants therapeutically. Together with the mutated Rb gene and the p53 gene, the present invention provides plasmids containing the mutated Rb gene or p53 gene. The present invention also provides a cell transfected with the plasmid of the present invention. Moreover, the present invention provides methods for treating various pathophysiological cell proliferative diseases. |