| abstract |
Benzenedicarboxylic acid diguanides of formula (1) are antiarrhythmic agents containing useful cardioprotective components, components for preventing ischemic induced damage, especially induction of ischemic induced cardiac arrhythmias. As a result of the inhibition of the cellular Na + / H + exchange mechanism, the drug is used for the treatment of acute or chronic damage due to ischemia. In addition, the drug is distinguished by an effective inhibitory effect on cell proliferation. The drug is suitable for the prevention of hypertension.n n n n n n n n In formula (1), R (1) to R (5) is as defined in the specification. |