| abstract |
The corneal therapeutic agent contains at least one of the hexapeptide or a pharmaceutically acceptable salt thereof represented by the formula (I) and a pharmaceutically acceptable carrier.n n n A-B-Pro-C-D-E (I)n n n Wherein A represents arginine or lysine in which the N-terminal amino group is deaminated, alkylated or acylated, B represents arginine, lysine or histidine, Pro represents proline, C represents tyrosine, tryptophan or phenylalanine , E represents a C-terminal carboxyl group, -COOR, -CH 2 OR or -CONHR (R represents a C 1 -C 4 alkyl group, and R represents a hydrogen atom or a C 1 -C 3 alkyl group), D represents valine, isoleucine or leucine, 4 > is an alkyl group having 1 to 4 carbon atoms), isoleucine or leucine, |