| abstract |
In the compound of general formula (I), Y is a linking group -COO-, -CH 2 COO-, CONH-, -CON (CH 3 )-, -CH 2 CONH-, -SO 2 NH-, -SO 2 NH ( It can be selected in various ranges including CH 3 )-and -PO (OC 2 H 5 ) NH-. W is an alkylene chain and A is a substituted phenyl group or a benzofuran or benzodioxane group. R and R 1 have various values, but suitably R is a macro group.n n n These compounds, and their prodrugs, diastereomers, stereoisomers, N-oxides, and pharmaceutically acceptable salts thereof, block the α 1A -adrenergic receptors, thus affecting the prostate, urethra, lower urethra, without affecting blood pressure. It is useful to prevent the contraction of. |