| abstract |
The present invention relates to benzoylguanidine of formula (I) and pharmaceutically acceptable salts thereof.n n n n n n n n Wherein R (1) is R (6) -CO or R (7) R (8) N-CO and R (2) is defined as R (1) or H, OH, Hal, CN, NO 2 , (perfluoro) alk (en) yl or-(CH) 2 R (15), or R (2) is (C1-C9) -heteroallyl, or R (2) is -SR (18), -OR (18), -NR (18) R (19) or -CR (18) R (19) R (20); Or R (2) is R (21) -SOm or R (22) R (23) N-SO 2- , or R (2) is R (33) X- [where X is oxygen, S, NR ( 34), (D = 0) A- or NR (34) C = MN ( * ) R (35)-] or R (2) is -SR (40), -OR (40), -NHR (40), -NR (40) R (41), -CHR (40) R (42), -CR (42) R (43) OH, -C≡CR (45), -CR (46) = CR (45) or-[CR (47) R (48)] u -CO- [C (R49) R (50)] V -R (44); Or R (2) is R (55) -NH-SO 2- , and R (3), R (4), R (5) are each independently defined as R (1) or R (2), At least one of R (2), R (3), R (4) and R (5) must be OH. |