| abstract |
The present invention uses a pyrimidine derivative of the following general formula (I) to inhibit sorbitol dehydrogenase, reduce fructose amount, diabetic neurosis, diabetic retinopathy, diabetic nephropathy or diabetic microvascular Or to a method for treating or preventing diabetic complications such as diabetic megaangiopathy and a pharmaceutical composition of the derivative.n n n n n n n n Wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined above.n n n The present invention also relates to novel substituted pyrimidines of the above general formula. The present invention also relates to a pharmaceutical composition comprising a co-drug precursor and aldose reductase inhibitor of a compound of formula (I) and a compound of formula (I) and an aldose reductase inhibitor. |