| abstract |
The present invention provides 2,5-diaryl tetrahydrofuran, 2,5-diaryl tetrahydrothiophene, 2,4, which reduces chemotaxis and respiratory explosions that form damaging oxygen radicals of inflammatory or immunoreactive polymorphonuclear leukocytes. -Diaryl tetrahydrofuran, 2,4-diaryl tetrahydrothiophene, 1,3-diaryl cyclopentane, 2,4-diaryl pyrrolidine and 2,5-diaryl pyrrolidine are disclosed. The compound acts as a PAF receptor antagonist, thus inhibiting the enzyme 5-lipoxygenase or exhibiting dual activity, i.e. as a PAF receptor antagonist and as an inhibitor of 5-lipoxygenase, Activity. The present invention also discloses a method of treating a disease mediated by PAF or leukotriene, which method comprises administering an effective amount of one or more of the compounds or their pharmaceutically acceptable salts, which may be contained in a pharmaceutically acceptable carrier. |