http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-940703812-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 |
| filingDate | 1992-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1994-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-940703812-A |
| titleOfInvention | Substituted tetrahydroisoquinolines and their use as therapeutic agents |
| abstract | FIELD OF THE INVENTION The present invention relates to tetrahydroisoquinoline compounds of formula (I), pharmaceutically acceptable salts thereof and O-acylated derivatives thereof in which anesthesia and psychosis (eg schizophrenia), Parkinson's disease, Lesh-Nian syndrome And lipophilic esters useful for the treatment of concentration deficit or cognitive impairment or for the alleviation of drug dependent or delayed dyskinesia.n n n n n n n n Wherein R 1 is H, halo, hydroxy, alkyl having 1 to 3 carbon atoms (optionally substituted by hydroxy), alkoxy having 1 to 3 carbon atoms, alkylthio having 1 to 3 carbon atoms, alkyl having 1 to 3 carbon atoms Optionally substituted by one or more substituents selected from sulfinyl, alkylsulfonyl of 1 to 3 carbon atoms, nitro, cyano, polyhaloalkyl of 1 to 3 carbon atoms (alkyl of 1 to 3 carbon atoms and alkoxy of 1 to 3 carbon atoms) ) Is one or more substituents selected from phenyl or carbamoyl optionally alkylated by one or two alkyl groups of 1 to 3 carbon atoms, R 2 of 1 to 3 carbon atoms optionally substituted by alkoxy or hydroxy of 1 to 3 carbon atoms An aliphatic group, E is an alkylene chain of 2 to 5 carbon atoms optionally substituted by one or more alkyl groups of 1 to 3 carbon atoms, G is phenyl or may be the same or different, Independently alkyl having 1 to 3 carbon atoms, alkoxy having 1 to 3 carbon atoms, halo, hydroxyl, polyhaloalkyl having 1 to 3 carbon atoms, polyhaloalkoxy having 1 to 3 carbon atoms, cyano, alkyl having 1 to 3 carbon atoms Thio, alkylsulfinyl having 1 to 3 carbon atoms, alkylsulfonyl having 1 to 3 carbon atoms, phenyl (optionally substituted with one or more substituents selected from halo, alkyl having 1 to 3 carbon atoms and alkoxy having 1 to 3 carbon atoms) Phenyl substituted by one or more substituents which are carbamoyl optionally alkylated by one or two alkyl groups of 1 to 3, or a phenyl ring to which a heterocyclic or aromatic carbocyclic ring is fused. |
| priorityDate | 1991-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.