http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-940018085-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7036 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4164 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate | 1993-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1994-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-940018085-A |
| titleOfInvention | Biolipophilic-containing liposome preparations and methods for preparing the same |
| abstract | The present invention is a microfluidizer equipped with a 0.22 μm filter for sterilization by mixing a phospholipid, a fat soluble and a water soluble bio oil, and a water soluble solvent. An ethanol solution containing 0.01-10% by weight of a thickening suspending agent, 0.001-5% by weight of antioxidants, 10-20% by weight of ethanol, and a fragrance as a minor component in the liposomes obtained, based on the total weight of the preparation. The present invention relates to a liposome preparation homogenized by addition of a microfluidizer under a pressure of 1000 to 5000 psi. According to the present invention, the liposome preparation is a sterilized liposome and a thickening suspending agent using a sterilizing filter. , Antioxidants and fragrances are dissolved in ethanol and composed of sterilized ethanol solution to prevent the collapse of phospholipids due to the incubation of microorganisms, Sterilization is maintained because 10-20% of ethanol is contained in the final product, and oxidation is prevented due to the reactivity of the phospholipid itself by the use of antioxidants, and since liposomes are completely suspended with a thickening suspending agent, The micelle formation with the surfactant does not occur, and the water-soluble substance is contained inside the liposome double membrane and the fat-soluble substance is contained in the double membrane itself, thereby preventing the water-soluble substance from leaking out of the double membrane by the fat-soluble substance of the double membrane itself. A stable liposome preparation can be obtained. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100385457-B1 |
| priorityDate | 1993-01-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.