| abstract |
The present invention provides methods and compounds for modifying polypeptides to polyethylene glycol (PEG) or other water soluble organic polymers. Novel water soluble polymer formulations are provided for this purpose.n n n Water-soluble polymer formulations of the present invention include hydrazine, hydrazine carboxylate, semicarbazide, thiosemicarbazide, carbonic acid dihydrazide, carbazide, thiocarbazide, and arylhydrazide derivatives and oxylamine derivatives of water-soluble organic polymers. Such as polyethylene glycol, polypropylene glycol, polyoxyethylated polyols, heparin, heparin fragments, dextran, polysaccharides, polyamino acids and polyvinyl alcohols.n n n Also provided are beneficial polypeptides derived by the water soluble polymer formulation of the invention.n n n Also provided are kits for modifying a polypeptide with a water soluble polymer formulation of the invention. |