| abstract |
The present invention provides methods for synthesizing modified ceramides and compositions containing iseramides for topical application to human skin, hair and nails. Modified pseudo-ceramides have the structure (1), roughly summarizing R and R 1 are aliphatic hydrocarbons and A is CH 2 , CHOR 2 , CH = CH or CHOY and at least one of R 2 , R 3 and R 4 is sulfate , Phosphate or the like.n n n The presence of phosphate or sulfate promotes skin absorption, after which the phosphate or sulfate is removed by an enzyme present in vivo. |