http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-930023361-A
Outgoing Links
| Predicate | Object |
|---|---|
| filingDate | 1992-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1993-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-930023361-A |
| titleOfInvention | N-acylate derivatives of anti-ulcer omeprazole and preparation method thereof, and preparation method of omeprazole using the same |
| abstract | The present invention relates to an N-acylate derivative (I) of omeprazole and a method for preparing the same, and a method for preparing omeprazole used as an ulcer therapeutic agent using the same, and an N-acetate derivative of omeprazole, a novel substance according to the present invention ( Ⅰ)n n n n n n n n (Wherein “R” represents a functional group selected from hydrogen atom, methyl, chloromethyl, trichloromethyl, bromomethyl, phenylmethyl or phenoxymethyl.)n n n 2-chloromethyl-3,5-dimethyl-4-methoxypyridine (II) was reacted with N-acyl-5-methoxy-2-mercaptobenzimidazole (III) to obtain thiether (IV) It is produced by oxidizing the thiether (IV).n n n n n n n n When the omeprazole is improved by using the method for preparing the N-acylate derivative (I) of omeprazole of the present invention, by-products such as chloromethylpyridine and N-acylbenzimidazole do not occur, and are in a stable solid form. It is possible to produce an intermediate product which is easy to separate, and to produce a compound of high purity using an enzymatic hydrolysis method. |
| priorityDate | 1992-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.