| abstract |
(a) a first monomer construct comprising a first mature cytokine protein (CP1), a first cleavable moiety (CM1), and a first dimerization domain (DD1), wherein CM1 is between CP1 and DD1 positioned, a first monomeric construct; and (b) a second monomer construct comprising a second mature cytokine protein (CP2), a second cleavable moiety (CM2), and a second dimerization domain (DD2), wherein CM2 is between CP2 and DD2. Provided herein are activatable cytokine constructs comprising a second monomeric construct, located at , wherein: CM1 and CM2 function as substrates for proteases; DD1 and DD2 bind to each other; and wherein the ACC is characterized by a decrease in at least one activity of CP1 and/or CP2 compared to a control level of at least one activity of CP1 and/or CP2. |