| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ec8dfdb16d4aca643208217a96aa9624
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_441f7c6829d19d1f693aa6ad677f2e8d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-04 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-132
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-41 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-60 |
| filingDate |
2021-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a7cb8294ccf73343d100c2d36e71277
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98d5e495d8c8d5f340607992bb3cc266
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ff188cd2b397de7e361253f5714b5d1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca0b870a922507649fb52b308d643692
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ee0a946ead0cf1c88db498bd50c5911
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d62a38fbe18c65d686609fd6481d32cf |
| publicationDate |
2022-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20220162364-A |
| titleOfInvention |
Novel squaramide derivatives and use thereof |
| abstract |
The present invention relates to a novel square amide derivative and its use, and provides a novel derivative that exhibits anticancer activity through eIF2α phosphorylation by using a strategy of substituting a urea parent compound with a bioisostere, square amide. Square amides contain a specific structure with a double bond linked to a carbonyl group. A square amide structure can be created by mediating a precursor having an amine group on a squarate ring of a square ring through a conjugate addition reaction. The present invention efficiently constructs a key intermediate in which an aniline ring with various substituents is introduced into a square amide, and utilizes this to provide a derivative in which a phenoxycyclohexyl structure is introduced to the opposite nitrogen. Since the synthesized novel derivative shows eIF2α phosphorylation effect and cancer cell proliferation inhibitory activity in vitro, it can be used as an anticancer agent. |
| priorityDate |
2021-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |