| abstract |
The present invention relates to a coronavirus (eg, Wuhan coronavirus (2019-nCoV; also referred to as SARS-CoV-2)) protein or a coronavirus (eg, Wuhan coronavirus (2019-nCoV); SARS-CoV-2) protein. It relates to immunogenic compositions or vaccines containing the encoding polynucleotides and uses thereof. The present invention also provides for treating and/or preventing a coronavirus (eg, Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) infection by administering an immunogenic composition or vaccine to a subject (eg, a human). provides a way to The present invention also relates to a protective anti-coronavirus (eg, Wuhan coronavirus (2019-nCoV; SARS-CoV-2)) antibody response (eg, anti-coronavirus antibody response, eg, anti-2019). Methods are provided for detecting and/or monitoring an -nCoV antibody response, eg, an anti-spike antibody response, eg, an anti-spike neutralizing antibody response. The present invention relates to isolated and/or recombinant nucleic acids encoding coronavirus S protein, in particular SARS-CoV-2 S protein, and to coronavirus S protein, as well as the use of the nucleic acid and/or protein thereof in vaccines . |