| abstract |
The compound (3-chloro-4-(4-(2-(2-hydroxypropan-2-yl)pyridin-4-yl)thiophen-2-yl)phenyl)(4-hydroxypiperidine -1-yl)methanone (Compound 1) and a pharmaceutically acceptable salt, solvate, tautomer, isotope, or isomer thereof are provided. Also disclosed herein is a component of the sterol regulatory element binding protein (SREBP) pathway, such as SREBP or SREBP cleavage activation protein ( SCAP) is provided. Further provided are methods of treating a disorder in a subject in need thereof, such as liver disease, nonalcoholic steatohepatitis, insulin resistance, or cancer. |