| abstract |
Provided herein is a delivery particle system (XDP) useful for delivery of any type of payload. In some embodiments, an XDP particle system having affinity for a target cell of interest is used to deliver a CRISPR/Cas polypeptide (eg, a CasX protein) and a guide nucleic acid (gNA) for modification of the nucleic acid in the target cell. . Also provided are methods of making and using such XDPs to modify nucleic acids in such cells. |