| abstract |
The present application relates to lipids of general formula (A) wherein at least one of the two side chains contains a carbonate functional group (M and/or M' is -OC(=O)O-) and such lipids, as well as phospholipids, structural empty or filled lipid nanoparticles (LNPs) comprising lipids and additional lipids such as PEG lipids. Lipid nanoparticles further comprising therapeutic and/or prophylactic agents such as RNA are useful, for example, for delivery of therapeutic and/or prophylactic agents to mammalian cells or organs for regulating polypeptide, protein, or gene expression. |