| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d07a4ddba85ae3e35ca0a6f85dad9f6d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_77e58a46a7ba5008f1f8e888cf52eca8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2535-122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6804
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2522-101
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-166
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6874
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2537-164
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2545-101
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2545-10 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6804
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1082
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1003
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6858 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6804
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
| filingDate |
2020-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af0348ffaecdd9febe96b8f6e36989c7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ff4b99c170687b9a0ead58dc2832876
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2137d0f1fe3284596e041c4c39fbb962
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edcb6db247246cc93eb840c5c1a7fe9d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b9b4e3255c38cc8a740f73a0333f2cb |
| publicationDate |
2022-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20220098183-A |
| titleOfInvention |
Synthetic spike-in controls for cell-free MEDIP sequencing and methods of use thereof |
| abstract |
Methods for capturing and analyzing cell-free methylated DNA in a sample are described herein. The method includes preparing the library for the sample to enable subsequent sequencing of cell-free methylated DNA. A predetermined amount of a control synthetic DNA fragment is added to the sample. Each of the control synthetic DNA fragments has a known nucleic acid sequence that does not align with the target genomic sequence, and at least a portion of the control synthetic DNA fragment is methylated. The sample is denatured, and cell-free methylated DNA and control synthetic DNA fragments are captured using a binding agent selective for the methylated polynucleotide. The captured DNA is amplified and sequenced. |
| priorityDate |
2019-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |