| abstract |
The present invention relates to compounds of formula (I): [Formula (I)] wherein R1 and R2 represent hydrogen or deuterium atoms; R3 represents a hydrogen atom or a -COOH, -OH or -OPO(OH) 2 group; R4 represents a hydrogen atom or a fluorine atom; R5 represents a hydrogen atom or an -OH group; wherein at least one of R3 or R5 is different from a hydrogen atom; when R3 represents a -COOH, -OH or -OPO(OH) 2 group, R5 represents a hydrogen atom; when R5 represents a -OH group, R3 and R4 represent a hydrogen atom; and R 6 is selected from an optionally substituted phenyl, heteroaryl, cycloalkyl or heterocycloalkyl group. The present invention also relates to the preparation of compounds of formula (I) and to their therapeutic use as inhibitors and degraders of the estrogen receptor, useful in particular for the treatment of cancer. |