| abstract |
Benzodiazepine derivatives of formula (I), and pharmaceutically acceptable salts thereof, are inhibitors of RSV and can therefore be used to treat or prevent RSV infection: From above: each R 1 and R 2 is independently H or halo; R 3 is H, C 1 -C 6 alkyl or —NHR 8 ; (i) , and are all bonds, , and is absent; or , and are all bonds, , and is absent; R 4 is H or a group selected from C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl and 4- to 10-membered heterocyclyl, said group being unsubstituted or substituted; R 5 is H or halo; R 6 is -OR 8 , -NR 8 R 9 or -R 8 ; R 7 is H or halo; each R 8 and R 9 is independently H or a group selected from C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl and 4- to 10-membered heterocyclyl, which group is unsubstituted or substituted; n is 1 or 2; one of V, W and X is N or CH and the other two are CH. |