| abstract |
Disclosed are agents for treating or preventing pain and/or inducing anesthesia and methods of using the same. The agent is a peptide, siRNA, and/or shRNA that targets adaptin protein 2-clathrin mediated endocytosis (AP2-CME). A peptide of the present disclosure may contain the following sequence X 1 X 2 X 3 X 4 L X 5 (SEQ ID NO: 7), wherein X 1 is D, E, S, or T, wherein D, E, S, and/or T is optionally phosphorylated, wherein X 2 , X 3 , and X 4 are each independently selected from any amino acid. |