| abstract |
A method of increasing lymphocyte count in a subject in need thereof, comprising: (i) a modified interleukin-7 of Formula (I): A - IL-7, wherein A is comprised of 1 to 10 amino acid residues an oligopeptide, wherein the IL-7 is a polypeptide capable of binding to an IL-7 receptor; or (ii) a second domain comprising an oligopeptide having 1 to 10 amino acid residues consisting of (a) modified interleukin-7, (b) methionine, glycine, or a combination thereof; and (c) administering to the subject an interleukin-7 fusion protein comprising a third domain that extends the half-life of the interleukin-7 fusion protein. |