| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4f0548ee4ecf77e552c58c637d6aa11 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-32 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0634
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0696
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-074 |
| filingDate |
2020-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcf5ef8099858c766bd47ae3d3ca82b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11833b56083b7e958d0b8c39681378fc |
| publicationDate |
2022-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20220070275-A |
| titleOfInvention |
Oligonucleotide-based ex vivo cell therapy |
| abstract |
The present invention provides a method of reducing the expression of a target RNA in an isolated cell in preparation for cell therapy, comprising incubating an isolated cell comprising the target RNA with an antisense oligonucleotide without the use of transfection means, , wherein the antisense oligonucleotide is administered at least once to the isolated cells within a period of 0 to 21 days, wherein the antisense oligonucleotide hybridizes with the target RNA from day 0 to up to 8 weeks of incubation with the antisense oligonucleotide to the target RNA It relates to a method for reducing the transcription of or reducing the expression of a protein encoded by a target RNA or a combination thereof. The present invention also relates to an isolated cell obtainable by the method of the present invention and a pharmaceutical composition comprising the isolated cell. The isolated cells and pharmaceutical compositions are used in methods of preventing and/or treating diseases. |
| priorityDate |
2019-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |