| abstract |
The present invention provides for the synthesis, pharmaceutically acceptable preparations and uses of a compound according to formula (I), or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. For compounds of formula I, X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and Rings A, B and C are as defined herein. The compounds of formula (I) of the present invention are inhibitors of eIF4e and have utility in any number of therapeutic applications including, but not limited to, the treatment of inflammation and various cancers. |