| abstract |
The present disclosure provides novel compounds represented by Formula I, wherein A 0 to A 2 , R 0 to R 6 , L, Z and Q are defined herein. The compounds of formula (I) are CHK1 inhibitors. Accordingly, the compounds of the present disclosure can be used to treat diseases, disorders and conditions, such as cancer, that are associated with sustained activation of CHK1, or that are associated with high internal DNA damage or damage during DNA replication. [Formula I] |