| abstract |
The present invention relates to the following formula I, which can modulate the activity of TMEM16a: [Formula I] (wherein all variables are as defined herein). The invention further provides methods for the preparation of the compounds of the invention and their therapeutic uses. The present invention further relates to a process for its preparation, its medical use, in particular COPD, bronchiectasis, asthma, cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, cystic fibrosis, primary ciliary dyskinesia, respiratory infections (acute and chronic ; viral and bacterial), to its use in the treatment and management of diseases or disorders, including lung carcinoma. |