| abstract |
The present disclosure provides compounds according to Formula I, Formula II, and pharmaceutically acceptable salts, tautomers, and/or isomers thereof, as described herein. The compound is an inhibitor of methionine adenosyltransferase isoform 2A (MAT2A). Also provided are pharmaceutical compositions and methods of using the compounds to treat cancer, including some cancers in which the gene encoding methylthioadenosine phosphorylase (MTAP) has been deleted. |