| abstract |
an antibody construct comprising an Fc domain; optionally one or more buffers, which are substances having at least one ionizable group having a pK a in the range of 3.0 to 9.5 and a pK a within 2 pH units of the pH of the composition; optionally one or more neutral amino acids; and an uncharged tonicity adjusting agent, wherein said aqueous solution composition at a pH in the range of 4.0-8.5, wherein said buffer is present in the composition at a total concentration of 0-5 mM; The total ionic strength of the composition excluding the contribution of the engineered protein construct is less than 20 mM. |