| abstract |
An oncolytic virus with improved safety and productivity is provided. Vaccinia virus growth factor (VGF), extracellular signal regulation kinase (ERK) activating protein, and ribonucleotide reductase (RNR) function are defective, do not replicate in normal cells, but replicate selectively in growing cells possible, limited-growth vaccinia virus with improved safety; The functions of VGF, ERK activating protein, and RNR are defective, and the gene encoding the extracellular enveloped virus (EEV)-related protein is substituted with a corresponding gene in another vaccinia virus strain having high EEV-producing ability, A restricted-growth vaccinia virus with improved safety and productivity that does not replicate in normal cells, but can selectively replicate in growing cells. |