| abstract |
Disclosed are compounds, compositions and methods of formula (I) for use in inhibiting the E3 enzyme Cbl-b in the ubiquitin proteasome pathway. The compounds, compositions and methods can be used to modulate the immune system, treat diseases that are compliant with immune system modulation, and can be used for cell therapy in vivo, in vitro, or ex vivo. pharmaceutical compositions comprising Cbl-b inhibitors and cancer vaccines as well as methods of treating cancer using Cbl-b inhibitors and cancer vaccines; and pharmaceutical compositions comprising a Cbl-b inhibitor and an oncolytic virus, as well as methods of treating cancer using a Cbl-b inhibitor and an oncolytic virus are also disclosed. Formula I |