abstract |
The present invention provides a composition comprising: a) two or more monomers each comprising the C-type lectin domain of CD23, wherein each monomer is capable of binding IgE; and b) an entity capable of binding to a neonatal Fc receptor (FcRn), wherein said protein construct comprises a linker, said linker comprising said monomer comprising a C-type lectin domain of CD23; It is used to connect to the entity that can be bound to. Also provided is a therapeutic use of the construct, eg, in an anti-IgE therapy, or a therapeutic use of the construct for use in the treatment or prophylaxis of a gE related disease or condition. |