http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20220016139-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0597f9c318d2aeca86db94711c516383 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39591 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 |
| filingDate | 2020-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6c042d6fa86b4ab6801f2174669cf6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc22372a272c27e4301309a6450f0283 |
| publicationDate | 2022-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20220016139-A |
| titleOfInvention | Hinge region engineering to induce antibody dimerization |
| abstract | The clinical potential of multispecific antibodies, such as bispecific and trispecific antibodies, appears to be very promising for the targeting of complex diseases. However, the generation of such molecules presents a great challenge, as in many cases where it is desirable to specifically induce specific pairings of multiple polypeptide chains present in solution. For the heavy chain, there are two major regions that form the dimer interface. One of these is the CH3 region, either by inserting charge pair mutations (CPM) to steer the dimer interface, or by inserting large bulky residues into the pores to physically favor and not favor dimer formation ( It has been widely used by Knob in Hole). However, each of these strategies cannot be applied to all molecules, and therefore more tools are needed. Herein, we describe engineering of the hinge region with a few mutations that alone can successfully induce heavy chain dimerization. |
| priorityDate | 2019-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 958.