| abstract |
The present invention relates to a lipophilic moiety, for example, a lipid, fatty acid, polyethylene glycol or a carboxyl present on the 3-O -glucuronic acid phase of a triterpene saponin to a non-acylated or desacylated triterpene saponin. It relates to novel chemical compounds attached covalently through groups. of saponins such as Quillaja desacylsaponins, lucioside P, or lipophilic moieties for 3-O -glucuronic acid of Gypsophila, Saponaria and Acanthophyllum Adhesion enhances its adjuvant effect in humoral and cell mediated immunity. In addition, attachment of a lipophilic moiety to the 3-O -glucuronic acid residue of a non- or des-acylsaponin is easier to purify than the original saponin, has little toxicity, is more chemically stable, and Produces saponin analogues with better adjuvant properties. |