abstract |
The present invention relates to formula I: [Formula I] It relates to a novel pyridazin-3-yl phenol compound of (wherein R 1 , R 2 , R 3 , R 4 , R 5 and Z are as defined herein), which is NOD-like receptor protein 3 (NLRP3). ) inhibits inflammasome activity. The present invention also relates to processes for their preparation, pharmaceutical compositions and medicaments containing them, and their use in the treatment of diseases and disorders mediated by NLRP3. |