http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20220008863-A

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filingDate 2020-05-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86fd2114751ac9aaa4f926fd1351d089
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66194230374d9c626eac35b6165b2f8d
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publicationDate 2022-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-20220008863-A
titleOfInvention Modified Adeno-Associated Virus (AAV) Particles for Gene Therapy
abstract The present invention relates to improved adeno-associated virus (AAV) particles for gene delivery and gene therapy. Adeno-associated virus (AAV) particles comprising a modified capsid are provided. The present invention also relates to the preparation of improved AAV particles of the present invention by removing the native binding sites of adeno-associated virus (AAV) capsids and introducing ligand binding sites into the capsid to provide AAVs that transduce only the specific cell of interest. it's about how A further aspect of the invention relates to modified AAV particles for use in the treatment of a disease and methods of treating a disease comprising administering to a subject in need thereof the modified AAV particles. Another aspect of the invention relates to the AAV particles of the invention for transfection of cells, for example as a gene delivery tool in basic research.
priorityDate 2019-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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