| abstract |
In order to bypass the Blood-Brain-Barrier (BBB) by the Peri-olfactory pathway, the present invention is administered intranasally by subolfactory mucosal injection, etc. or intramaxillary bone It relates to a pharmaceutical composition comprising mesenchymal stem cells derived from the nasal inferior turbinate as an active ingredient, characterized in that it is administered, and the stem cells are injected into the nasal cavity to olfactory and trigeminal neural pathways. Through this method, it is possible to efficiently deliver various therapeutic substances, including stem cells, to the brain and nervous system. It is possible to obtain inferior turbinate-derived mesenchymal stem cells, and it has the same genetic origin as the administering subject, so it has fewer side effects, but has the same or superior effect to bone marrow-derived mesenchymal stem cells or adipose-derived mesenchymal stem cells It is expected that various therapeutic substances, including nasal inferior turbinate-derived mesenchymal stem cells, can be administered intranasally to minimize side effects and to be used for the prevention or treatment of neurological diseases. |