abstract |
Tyrosine hydroxylase (TH) variants lacking 60 to 120 amino acid residues at the N-terminus, and TH variants lacking 60-120 amino acid residues at the N-terminus and aromatic L-amino acid decarboxylase (AADC) A pharmaceutical composition comprising it is provided. Also provided is a nucleotide construct, vector plasmid, cell, or virus comprising a TH variant, or use of the virus in the manufacture of a pharmaceutical composition as well as a medicament for treating a neurodegenerative disease such as Parkinson's disease. |