| abstract |
The present inventors succeeded in improving the stability under acidic conditions in the constant region of the antibody, the heterogeneity derived from the disulfide of the hinge region, the heterogeneity derived from the C-terminus of the H chain, and the stability in the high concentration formulation. did Additionally, while minimizing the appearance of new T-cell epitope peptides, we succeeded in discovering a novel constant region sequence that reduced binding to Fcγ receptors. In this way, we succeeded in discovering an antibody constant region with improved physical properties (stability and uniformity), immunogenicity, safety, and pharmacokinetics. |