| abstract |
The present invention relates to an oral pharmaceutical composition comprising a cholinergic drug, in particular a natural plant alkaloid selected from the group consisting of lobelin, anabacin, cyticine, galantamine or an acceptable salt thereof, in tablet and capsule form. Excipients of the developed oral composition include cellulose powder, calcium sulfate, colloidal silica and magnesium stearate, wherein the total content of cellulose powder and calcium sulfate dihydrate is 64.5 to 97.5% of the mass of the dosage form and at least 90% of the alkaloid particles ≤ 100 μm. The oral composition also comprises at least one biologically active amino acid selected from L-carnitine, tryptophan, or a combination thereof. Oral compositions according to the invention achieve a uniform composition of the active substance in the composition as well as stability of the composition due to the included excipients selected to react minimally with the alkaloids to form acceptable qualitative and quantitative relevant substances in the pharmaceutical composition. The composition according to the invention is applicable in the treatment of dependence and addiction to nicotine, tobacco products and alcohol. |