| abstract |
The present invention inhibits inflammasome activation by Alu RNA associated with cells, reduces ATP-induced permeability of cells, reduces the amount of mitochondrial reactive oxygen species in cells, and reduces mitochondrial reactive oxygen species in cells Compounds, compositions and methods useful for treating retinal damage and/or retinal degeneration/retinal degeneration for reducing the amount of The present invention also protects RPE cells and/or pathologies associated with retinal damage and/or degeneration, including age-related dry macular degeneration (AMD) and wet AMD, Alzheimer's disease, various forms of arthritis, atherosclerosis, diabetes , to compounds, compositions and methods for use in the treatment and prophylactic treatment of chronic obstructive pulmonary disease, inflammatory bowel disease and Duchenne's muscular dystrophy. |