http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20210151918-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_67261161a8fc89052115e48d3f1138de |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70596 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 |
| filingDate | 2020-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89ed93313ec5d72272e085cd1e5631e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3dec80d345f3e18b6ebc51464dddeb5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d4f9678120fef3009298ce0048d54a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9478ce6803e5f4159492bf5d78f3cc3b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b26b53832c2651d45357747d0c397c45 |
| publicationDate | 2021-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20210151918-A |
| titleOfInvention | DAF-MCP chimeric protein, method for its preparation and use of said chimeric protein for the treatment of pathological conditions related to the complement system |
| abstract | The complement system is part of the innate immune system and is highly regulated by regulatory proteins belonging to the complement activation regulator (RCA) family. Lack of regulation causes damage to host cells, and deficits in regulation are also known to be associated with diseases such as, for example, age-related macular degeneration, atypical hemolytic uremic syndrome, and dense deposit disease. Regulatory proteins mainly include decay promoting factor (DAF; CD55), membrane cofactor protein (MCP; CD46), complement receptor 1 (CR1; CD35), factor H (FH) and C4b-binding protein (C4BP). Structurally, these proteins are composed of repeating complement control protein (CCP) domains in which 2-4 contiguous domains contribute to regulatory functions of decay-promoting activity (DAA) and cofactor activity (CFA). However, there are currently no four domain chimeric proteins with both potent DAA (CP-DAA and AP-DAA) and potent CFA (C3b-CFA and C4b-CFA). Thus, the chimeric protein DCP (ie, dual activity regulator) was generated. |
| priorityDate | 2019-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 312.